795 Predictors and Timing of Recurrence After Surgical Resection of Pancreatic Adenocarcinoma

Abstract Aim To investigate the predictors and timing of recurrence after curative resection for pancreatic adenocarcinoma (PDAC). Method Consecutive patients who underwent PDAC (2011-21) consented to data tissue collection, were followed up prospectively in a single institution. Clinico-pathological variables analysed using Cox proportional hazards model. Results 91 (median age 71 years (range 43 – 86)) had median follow-up 51 (95% CI 40–61) months. 66 (72.5%) experienced (12 locoregional, 11 liver, 5 lung, 3 peritoneal, 29 simultaneous locoregional distant 6 multi-focal distant). Median time was 8.5 6.6-10.5) months survival 5.8 4.2-7.3) Stratification by location revealed no significant differences (p = 0.24). Significant any lymph node ratio ≥0.33 0.005, HR 2.8, 95% 1.4 5.8), adjuvant chemotherapy 0.002, 0.4, 0.2 0.7) systemic inflammation score ≥500 0.01, 4.5, 14.3). Conclusions Lymph ratio, PDAC: this needs validation large national cohorts.